The big retailers that are at the core of supply chain play a vital role in stability and value-added of supply chain,especially the gradual penetration of E-commerce.This paper research on the basis and reflect of core position?about big retailers in supply chain by using theory of?constraints.And it also plays?a?significant?role in supply chain ,which can make it better in coordinating operation of all enterprises in supply chain.As a result, it could improve the whole profit of supply chain.