Successful biotechnology highly relies on innovation network, which can integrate knowledge, human, capital and market from academia and industry. Using CNKI paper data and methods from bibliometrics and social network analysis, it aims to study the collaboration pattern of Chinese biotechnology at author, affiliation and region level, and especially the roles of regions in the collaboration network. Results show that more than 96% papers include author collaborations and the most common pattern is collaboration within no less than three authors from one affiliation. When affiliation collaborations happen, they prefer to choose partners from other regions.