Recently, prime minister Li Keqiang has repeatedly stressed that innovation is the key "to build China's economic promotion version". In order to realize the transformation and upgrading of industrial clusters, it is the key that enterprises’ technology innovation and cooperation in the industrial cluster. Cooperative game and technology innovation in industry cluster has the condition. Cooperative game can be achieved on the analysis of participants and dynamic. To maintain the cooperation game, there must be a benefit allocation and coordination mechanism. The government should also turn industrial policy into the innovation of science and technology policy.