There are more opportunities for knowledge innovation in cooperation while there are more possibilities for these enterprises to ‘take free bus’. It’s necessary to build up encourage mechanism for cooperation knowledge innovation. Some mechanism based on price division cannot be used in the process of knowledge innovation and some satisfaction model based on salary could not be used in it because there is no salary in knowledge innovation. On foundation of feeling of profit and payment, satisfaction model is put forward with desired earning, valued earning, desired payment and valued payment. Then psychological account is used in this model to analyze how satisfaction model is modified under positive and negative emotion. Some encouragement strategies are formed according to this. And a case of regional medical cooperation platform is introduced.