It’s a imminent task to resolve the financial problems of our SCI-TECH businesses. At present, commercial banks’ loan is the main financial channel for our SCI-TECH businesses. But the traditional credit appraisal system dose not apply to the SCI-TECH businesses, and cannot effectively solve the asymmetry problems. So we must establish scientific growth appraisal system of the SCI-TECH businesses. The growth appraisal system of the SCI-TECH medium-sized businesses includes 6 one-class indexes and 58 two-class indexes, which are processed and empowered through various methods. The appraisal system establishes a foundation platform for appraising the growth of the SCI-TECH medium-sized businesses and developing commercial banks’ science finance.