The coordinated development of science and technology and economy is the important content of Scientific Outlook on Development. The coordinate coefficient models of regional science and technology—economic system have been built based on synergetic theory in this paper. The harmony between science and technology and economy in recent ten years of Zhejiang Province has also been estimated in the terms of the model. In order to put forward some countermeasures and suggestions to improve the coordination of science and technology—economic system in Zhejiang Province, further research on how to control the technology - economy system coordination is also proposed.