We have stepped into a new age named post-IT age which presents new features. Small and medium enterprises are experiencing the unprecedented opportunity and challenge in the new age. This paper specially analyses the features of post-IT age and the problems happening in small and medium enterprises in this background, and then directly points out that the main reason is lack of integrate application of information resource. Basing on these problems, this paper presents small and medium enterprises should conduct micro-creative and deep innovation strategy which performs well in the post-IT age background.