Industrial economy as an important part of urban economy, playing more and more important role in the development of urban economy , regional industry leading industry to establish a reasonable choice of regional industry division of labor system and realize the coordinated development of regional economy continued to important influence and significance. In recent years, with the rapid development of nanjing industrial economy, nanjing industrial leading industries also changes take place, this paper uses the method of combining the leading industry in dynamic and static and choosing pillar industry for nanjing, on the basis of analysiing nanjing respectively the new dominant industry and the pillar industry, find out the existing problems, finally giving the countermeasures and suggestions for nanjing industrial economic development, providing basis for the scientific decision.