Power industry layout not only affects energy production and consumption patterns, but also affects the regional economic development. Based on the 2007 input-output tables, the study construct multi-regional dynamic computable general equilibrium model and comparatively analyzed the impact of two different modes of coal power layout on the regional economic development. The result shows that inter-regional allocation is conducive to stimulate economic growth of send-end region, promote the rational division of industry and bridge the gap between regions, compared to regional allocation.