According to the real data of Heilongjiang Province patent development from 2000 to 2008, established model of based on the least squares method and Cobb-Douglas function，and made the future development trend of patent output forecast of Heilongjiang Province, and analyzed correlated factors affected patent output. The results shown that the future of the patent output for Heilongjiang Province would be increasing within the next few years, and the growth rate of R&D expenditures would be greater than the output of the patent; R&D input has no significant effect on output of the patent, however the number of person, including scientists and engineers, and a variety of active policy with simulating them significantly associated with the output of patent.