This article studies the relationship between the members enterprise of current industry technology innovation strategic alliance,based on the perspective of game theory. Through the establishment of basic assumptions, building a game decision trees between the enterprises, while establishing static game model under the conditions of perfect information and imperfect information, the paper finds the Nash equilibrium solution. In in the process of solving the game, the article reveals the core issues of trust mechanism of member enterprises, and finds the mechanisms and methods solving the problem of mutual trust and cooperation of member enterprises.