On the basis of the DEA method,this paper evaluates overall technical efficiency, pure technical efficiency and scale efficiency for 37 sub-sectors of Large and Medium-sized Industrial Enterprises in Anhui province in 2009 from the perspective of production efficiency,and analyses the units in different skill levels by Quantitative method. Then recognizes the inefficiency factors of industrial production based on Tobit Model. It finds that: (1)industies in the different skill levels are still at a relative low level of production efficiency,and pure technical inefficiency is the main cause;(2) The phenomena of employees crowded and output insufficiency is generally existing in Infustry production.(3)Industry Performance is the most important factor evidently affecting the industial production inefficiency.