In the global trend of entering the digital economy era, the digital innovation and transformation of the manufacturing industry has become a key development trend that drives the global manufacturing industry to leap forward. This transformation process has deeply integrated the essence of information technology and manufacturing technology, and injected a strong and lasting power source into the high-quality and efficient development of the manufacturing industry. How digital transformation enables high-quality development of manufacturing industry were deeply explored, and the corresponding theoretical framework and implementation path were built. First, the connotation, characteristics and internal relationship between digital transformation and high-quality development of manufacturing industry are analyzed. Second，construction strategy of digital transformation enabling high-quality development of manufacturing industry is put forward, and verifies its effectiveness by case analysis. Finally, the prospect of digital transformation in the high-quality development of manufacturing industry is prospected.