The liquefaction of soil is one of the main causes of damage caused by the earthquake, Accurate discrimination of liquefaction has become the focus of research. Therefore, the seismic liquefaction discrimination is a very important work in the regional site seismic safety evaluation. To ensure the accuracy and reliability of the evaluation results, Taking the regional seismic safety evaluation project of Plot 2 of Yangyuan Economic Development Zone, Zhangjiakou City as the research background, the methods and processes of seismic liquefaction evaluation in the seismic safety evaluation of regional sites was studied, in order to provide a scientific basis for the seismic safety evaluation work. The research results can provide a reference and guiding significance for how to carry out seismic liquefaction evaluation on regional sites.