Abstract:Taking all the cities in the Twin Cities Economic Circle of Chengdu-Chongqing region as the research object, the panel data from 2010 to 2020 was used as the sample, the regional collaborative innovation index system was constructed, the coupling synergy model was established, and its collaborative innovation ability was measured. The location entropy of segmented industries in the economic circle in 2019 was calculated to analyze the degree of industrial specialization. The empirical results show that the level of collaborative innovation in the Chengdu-Chongqing area is increasing year by year, but there are still a series of problems. Finally, suggestions are proposed for the current status quo. On the one hand, it is necessary to base on traditional industries while developing emerging industries. On the other hand, it is necessary to coordinate the resource sharing mechanism and transform the institutional mechanism of industrial collaborative innovation.