The problem of airport site selection involves many factors which may be incompatible with each other. To solve this problem, a fuzzy matter-element analysis method based on combinatorial weights is proposed. Firstly, the factors affecting airport site selection are analyzed, the index system of airport site selection is established, and the weight of each index is determined by combination weighting method. Then, the membership degree of the scheme to the index is determined based on the expert's opinion, and the fuzzy matter-element model was established. Finally, the Euclidean closeness degree is used to select the optimal scheme. The results show that the optimal scheme can be obtained by using this method, and it is consistent with the optimal scheme obtained by the verification method, which proves its correctness.