Abstract:The big health industry is one of the most promising and sustainable developing industries in 21st century. This article researches and defines the concept of big health on industrial investment perspective, start from sorting out the ecology and development status of big health industry, it deeply analyzes the problems and difficulties in development of Yunnan’s big health industry based on statistical data. On the basis, the article puts forward suggestions and implementation routes for the sustainable development of Yunnan's big health industry from the bio-medicine, health services and health real estate aspect, in the hope of making contributions to improving the sustainable development and value creation ability of Yunnan's big health industry.