Summarizes the connotation of the great change that has not happened in the past 100 years and expounded the connotation of the safety of manufacturing industry chain. Then, analyzes the impact of the great change on Chinese manufacturing industry chain from two aspects that were challenges and opportunities, demonstrates the importance of ensuring the safety of manufacturing industry chain. Finally, gave the path to ensure the safety of manufacturing industry chain, such as ensuring self-control, improving international competitiveness, achieving sustainable development,and put forward the following suggestions: "strengthen the government's reasonable intervention and guidance, polish the internal strength of industrial technology", "increase the export and foreign investment of manufacturing industry, improve the influence of independent brand", "improve the relevant system construction, and create a new brand that are beneficial to the development pattern of big circulation and double circulation.