Huai-heng railway is an express railway which opened passenger transport in December 2018. Optimizing transport organization plays an important role in improving its operation efficiency. Based on analysis of the location in railway network and technical conditions of the line, the regional economic and social situation along the railway line, optimizing principle and method of the line operation division and train plan are discussed. Combined with associated passenger trains and passenger flows, the optimal scheme of crossing trains, part-crossing trains and line trains are hierarchically designed, the optimization trains scheme accords with passenger demands, and the results have been partly applied to the new trains diagram. Finally, some suggestions are put forward to further improve the operation efficiency of huai-heng railway.