Taking the “Belt and Road” domestic 18 provinces (cities) as the research object, based on the inter-provincial panel data from 2009 to 2018, the location entropy is used to measure the level of logistics industry agglomeration, and then the global Moran's I is used to guide the “One Belt and One Road” along the domestic line. Regional GDP is analyzed for spatial dependence characteristics. On this basis, the construction of spatial measurement model empirically tested the impact of logistics industry agglomeration on regional economic growth. The results show that the implementation of the “Belt and Road Initiative” promotes the concentration and development of the logistics industry along the domestic market; the logistics industry agglomeration has a strong correlation with the regional economic development, and has significant economic spillover effects in space.