With the rich output of scientific and technological achievements in universities, the distribution of benefits has become an important factor affecting the success of its transformation. Based on the patents granted by universities, it is great significance to study the distribution of benefits from the beginning conversion to the successful conversion. Firstly, determine the university, enterprise and patent conversion team as the main body of interest distribution; secondly, based on the contribution degree of each subject, apply Shapley value method to calculate its due benefit; finally, consider the difference between the subjects in the process of transformation, select the four elements, the degree of innovation, the degree of effort, the degree of risk tolerance and the contribution of marketing promotion optimize, to correct the model, and obtain a more reasonable distribution of benefits.