Abstract:On February 26, 2014, when inspected in Beijing, General Secretary Xi Jinping first identified the Center for Science and Technology Innovation as one of the four core functions of the capital. The construction of national science and technology innovation center is an important measure for transforming the economic development mode and enhancing the comprehensive competitiveness of the country in the new normal. It is the new responsibility that the Central Government entrusts Beijing with. It is not only the mission of Beijing but also the only way for its development. The core element is talent in the construction of National science and technology innovation center, therefore, as Beijing Research Institutes, it is imperative to strengthen the building of talent team, enhance the ability of scientific and technological innovation and to transform scientific and technological achievements so as to serve the construction of national science and technology innovation center. This article selects the largest and multidisciplinary, cross-industry municipal Beijing city research institution as a research object, Through in-depth analysis of the status, problems and challenges of its talent work, combined with the needs of talent in science and innovation centers, this paper puts forward the countermeasures of talent work with common features and individual characteristics from the aspects of the introduction of high-end talents, the cultivation and encouragement of young talents, for other Beijing city research institutes to provide reference.