Abstract:With the continuous deepening of the supply-side reform in China, the society has put forward new challenges to the demand for talents’ quality and the cultivation of talents in local colleges and universities. On the basis of the analysis of the targets of cultivating application-oriented undergraduate talents and the characteristics of applied-innovative talents, under the background of supply-side reform, this paper puts forward the application-oriented transformation path of local undergraduate universities from the aspects of transformation and development strategy, the orientation of running a school, the teaching staff, and talent training mode.