Abstract:The regional science and technology innovation center is a major strategy for many countries and regions to enhance their comprehensive competitiveness and cope with a new round of scientific and technological revolution. In the wave of promoting the transformation of old and new kinetic energy in Shandong, strengthening the construction of regional science and technology innovation center is significant. Based on the centralized analysis of policy documents and the understanding of the connotation and characteristics of regional science and technology innovation center, the paper summarizes the strategic positioning of Shandong regional science and technology innovation center, systematically expounds the significance , and from provincial and municipal areas, the strategic initiatives for strengthening the construction of regional science and technology innovation centers are proposed.